AI GLS Strain Imaging in Multi-Vendor Comparison Study

AI GLS Strain Imaging in Multi-Vendor Comparison Study

Ten years after the first head-to-head comparison of two-dimensional speckle-tracking echocardiography derived GLS measurements obtained with software solutions from different vendors, the authors compared again GLS results from 3-vendor-specific and 6-vendor agnostic software solutions in a cohort of patients and volunteers with a wide range of LV function. 

Us2.ai’s Feature in this Study:

Us2.ai was among the vendor-agnostic solutions included in this updated comparison. GLS analysis with our fully-automated AI software demonstrated:

  • Zero operator input required, operating without any human intervention
  • High agreement with traditional semi-automated speckle- tracking software solutions, validating clinical accuracy.
  • Support for broader clinical adoption, by reducing inter-operator variability and enabling scalable strain imaging across platforms.


Balinisteanu, A., Duchenne, J.,  Puvrez, A., Wouters, L., Bézy, S., Youssef, A., Minten, L., Bekhuis, Y., van Langenhoven, L.,  Papangelopoulou, K., Cieplucha, A., Cattapan, I., Tostes, P., Bogaert, J., Vinereanu, D., Thomas, J. D., Badano, L., & Voigt, J.-U. (2025). Vendor Differences in 2D-Speckle Tracking Global Longitudinal Strain: An Update on a Ten-Year Standardization Effort. European Heart Journal – Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jeaf155