Article | Jun 11, 2025

Ten years after the first head-to-head comparison of two-dimensional speckle-tracking echocardiography derived GLS measurements obtained with software solutions from different vendors, the authors compared again GLS results from 3-vendor-specific and 6-vendor agnostic software solutions in a cohort of patients and volunteers with a wide range of LV function.

Us2.ai's Feature in this Study:

Us2.ai was among the vendor-agnostic solutions included in this updated comparison. GLS analysis with our fully-automated AI software demonstrated:

  • Zero operator input required, operating without any human intervention
  • High agreement with traditional semi-automated speckle- tracking software solutions, validating clinical accuracy.
  • Support for broader clinical adoption, by reducing inter-operator variability and enabling scalable strain imaging across platforms.

Download and read the full manuscript here →


Balinisteanu, A., Duchenne, J., Puvrez, A., Wouters, L., Bézy, S., Youssef, A., Minten, L., Bekhuis, Y., van Langenhoven, L., Papangelopoulou, K., Cieplucha, A., Cattapan, I., Tostes, P., Bogaert, J., Vinereanu, D., Thomas, J. D., Badano, L., & Voigt, J.-U. (2025). Vendor Differences in 2D-Speckle Tracking Global Longitudinal Strain: An Update on a Ten-Year Standardization Effort. European Heart Journal – Cardiovascular Imaging. https://doi.org/10.1093/ehjci/jeaf155